Preferred Label : Anti-NaPi2b Antibody-drug Conjugate XMT-1592;
NCIt synonyms : Anti-NaPi2b/Auristatin F-HPA ADC XMT-1592; Anti-NaPi2b ADC XMT-1592; NaPi2b-targeted Antibody-drug Conjugate XMT-1592;
NCIt related terms : XMT-1592;
NCIt definition : An antibody-drug conjugate (ADC) composed of XMT-1535, a humanized monoclonal antibody
against human sodium-dependent phosphate transport protein 2B (SLC34A2; NaPi2b), that
is site-specifically bioconjugated to the cytotoxic aurastatin derivative auristatin
F-HPA (AF-HPA; auristatin F-hydroxypropylamide), with potential antineoplastic activity.
Upon administration of anti-NaPi2b ADC XMT-1592, the antibody moiety targets and binds
to NaPi2b expressed on tumor cells. Following internalization of XMT-1592 and release
of AF-HPA, the AF-HPA binds to tubulin and inhibits microtubule polymerization, which
results in G2/M phase arrest and apoptosis of NaPi2b-expressing tumor cells. NaPi2b,
a tumor-associated antigen (TAA), is overexpressed on a variety of cancer cells and
plays a key role in the transport of inorganic phosphate (Pi) and the maintenance
of phosphate homeostasis.;
UNII : M4Q33GWL9S;
Molecule name : XMT-1592; XMT 1592;
NCI Metathesaurus CUI : CL1407519;
Origin ID : C173702;
UMLS CUI : C5418017;
Semantic type(s)
- concept_is_in_subset
- has_target
