Preferred Label : Rucosopasem Manganese;
NCIt synonyms : SOD Mimetic GC4711; Superoxide Dismutase Mimetic GC4711; Avasopasem Manganese Dipropionate;
NCIt definition : A mimetic of the enzyme superoxide dismutase (SOD) that may potentially be used to
increase the anti-cancer efficacy of stereotactic body radiation therapy (SBRT). Upon
administration, rucosopasem manganese may mimic native SODs and catalyze the formation
of molecular oxygen and hydrogen peroxide from the burst of superoxide anion present
in the irradiated tissues upon radiation. As hydrogen peroxide is less toxic than
superoxide to normal tissues, but more toxic to cancer cells, this may increase the
anti-cancer efficacy of SBRT and decrease its damage to normal tissues.;
UNII : FW5T90VM32;
CAS number : 2248030-85-3; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2248030-85-3
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G-SRS /a ;
Molecule name : GC-4711; GC 4711;
NCI Metathesaurus CUI : CL1407386;
Origin ID : C173664;
UMLS CUI : C5667206;
Semantic type(s)
- concept_is_in_subset
