Preferred Label : Anti-CD38/CD28xCD3 Tri-specific Monoclonal Antibody SAR442257;
NCIt synonyms : Tri-specific T-cell Engager SAR442257;
NCIt definition : A tri-specific T-cell engager and monoclonal antibody targeting CD38, a human cell
surface glycoprotein and tumor-associated antigen (TAA), CD3, a T-cell surface antigen,
and CD28, a T-cell specific surface glycoprotein and co-stimulatory molecule, with
potential antineoplastic activity. Upon intravenous administration, anti-CD38/CD3/CD28
tri-specific monoclonal antibody SAR442257 targets and binds to CD3 and CD28 on T-cells
and CD38 expressed on tumor cells. The resulting cross-linkage may trigger a potent
cytotoxic T-lymphocyte (CTL) response against CD38-expressing tumor cells. In addition,
SAR442257 can also directly target CD28 expressed on tumor cells, such as multiple
myeloma cells, thereby enhancing the anti-tumor activity of this agent and allowing
it to bind to tumor cells when CD38 is occupied by other antibodies. CD38, a type
II transmembrane glycoprotein, is present on various immune cells and hematologic
malignancies; its expression has been correlated with poor prognosis.;
Molecule name : SAR 442257; SAR-442257;
NCI Metathesaurus CUI : CL1407369;
Origin ID : C173645;
UMLS CUI : C5418010;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
