Preferred Label : TRK Inhibitor TQB3558;
NCIt synonyms : Tropomyosin Receptor Kinase Inhibitor TQB3558;
NCIt definition : An orally available inhibitor of tropomyosin receptor kinase (Trk), with potential
antineoplastic activity. Upon oral administration, Trk inhibitor TQB3558 targets and
binds to Trk, thereby preventing neurotrophin-Trk interaction and Trk activation.
This may lead to apoptosis of Trk-expressing tumor cells and the inhibition of tumor
cell proliferation in Trk-expressing tumors. Trk, a receptor tyrosine kinase activated
by neurotrophins, is mutated in a variety of cancer cell types and plays an important
role in tumor cell growth and survival.;
Molecule name : TQB 3558; TQB-3558;
NCI Metathesaurus CUI : CL1407328;
Origin ID : C173560;
UMLS CUI : C5418002;
Semantic type(s)
- concept_is_in_subset
