Preferred Label : Anti-5T4 Antibody-drug Conjugate ASN004;
NCIt synonyms : Anti-5T4 ADC ASN004; 5T4-targeted Antibody-drug Conjugate ASN004; 5T4-ADC ASN004; 5T4-targeted Dolaflexin ADC ASN004;
NCIt definition : An antibody-drug conjugate (ADC) composed of an antibody directed against 5T4 and
conjugated, via a non-cleavable linker, to a proprietary polymer carrying multiple
auristatin analog molecules via a cleavable linker, with potential antineoplastic
activity. Upon administration, the antibody moiety of ASN004 selectively binds to
cells expressing the 5T4 oncofetal antigen. After internalization and cleavage within
the tumor cell cytosol, free auristatin analog molecules binds to tubulin and inhibits
its polymerization, which may result in G2/M phase arrest and tumor cell apoptosis.
5T4, a transmembrane glycoprotein, is overexpressed by a variety of cancer cell types;
its expression is correlated with increased invasiveness.;
Molecule name : ASN 004; ASN-004;
NCI Metathesaurus CUI : CL1407317;
Origin ID : C173556;
UMLS CUI : C5417999;
Semantic type(s)
- concept_is_in_subset
- has_target
