Gallium Ga 68-DOTA-FAPI-04

Preferred Label : Gallium Ga 68-DOTA-FAPI-04;

NCIt synonyms : 68Ga-FAPi-04; Gallium-68-FAPi-04; 68Ga-DOTA-FAPI-04;

NCIt related terms : GALLIUM GA-68-DOTA-FAPI-04;

NCIt definition : A radioconjugate composed of FAPI-04, a quinoline-based fibroblast activation protein (FAP)-targeted tracer belonging to the group of FAP inhibitors (FAPi), conjugated, through the macrocyclic chelator 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA), to the radioisotope gallium Ga 68, with potential use as a tracer for FAP-expressing cancer-associated fibroblasts (CAFs) during positron emission tomography/computed tomography (PET/CT). Upon administration of gallium Ga 68-DOTA-FAPI-04, the FAPI-04 moiety targets and binds to FAP-expressing CAFs. Upon binding, FAP-expressing cells can be detected during PET/CT imaging. FAP, a cell surface protein, is overexpressed on CAFs in the tumor microenvironment (TME).;

UNII : ZZ7STN2LBB;

CAS number : 2374784-95-7;

NCI Metathesaurus CUI : CL1638345;

Details

Origin ID

C173538;

UMLS CUI

C5392518;

Currated CISMeF NLP mapping
- 68Ga-FAPI [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Indicator, Reagent, or Diagnostic Aid [UMLS semantic type]
UMLS correspondences (same concept)
- 68Ga-FAPI [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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