Preferred Label : Carbon C 14-pamiparib;
NCIt synonyms : [14C]-pamiparib; 14C-pamiparib;
NCIt definition : An orally bioavailable radioconjugate composed of pamiparib, a nuclear enzyme poly(ADP-ribose)
polymerase (PARP) inhibitor, radiolabeled with the radioisotope carbon C 14, with
potential use for evaluating the pharmacokinetic profile of pamiparib. Pamiparib targets,
binds to and inhibits PARP, which results in the inhibition of tumor cell proliferation
and survival. Labeling of pamiparib with the radioactive tracer carbon C 14 allows
for the evaluation of pamiparib's pharmacokinetic profile, including its absorption,
distribution, metabolism and excretion (ADME).;
NCI Metathesaurus CUI : CL1407424;
Origin ID : C173441;
UMLS CUI : C5420202;
Semantic type(s)
- concept_is_in_subset
