Preferred Label : Hetrombopag Olamine;
NCIt synonyms : (Z)-5-(2-Hydroxy-3-(2- (3-methyl-5-oxo-1-(5,6,7,8-tetrahydronaphthalen- 2-yl)-1H-pyrazol-4(5H)-ylidene)hydrazinyl)phenyl)
Furan-2-carboxylic Acid Diethanolamine; SHR8735 Olamine;
NCIt related terms : RAFUTROMBOPAG OLAMINE;
NCIt definition : The orally active ethanolamine salt of hetrombopag, a small-molecule, nonpeptide thrombopoietin
receptor (TPO-R or CD110) agonist, with megakaryopoiesis-stimulating activity. Upon
oral administration, hetrombopag targets, binds to and stimulates the transmembrane
domain of the platelet TPO-R, a member of the hematopoietin receptor superfamily.
Activation of TPO-R leads to the proliferation and differentiation of cells in the
megakaryocytic lineage and an increase in platelet production. This may prevent or
treat chemotherapy-induced thrombocytopenia.;
UNII : V45T2I862X;
InChIKey : LEXFXZIVRDMLHQ-SBIAVEDLSA-N;
CAS number : 1257792-42-9;
NCI Metathesaurus CUI : CL1407414;
Origin ID : C173439;
UMLS CUI : C5418132;
Semantic type(s)
- concept_is_in_subset
