Preferred Label : Tunlametinib;
NCIt synonyms : 4-Fluoro-5-((2-fluoro-4-iodophenyl)amino)-N-(2-hydroxyethoxy)-6-benzothiazolecarboxamide; MEK Inhibitor HL-085; 6-Benzothiazolecarboxamide, 4-fluoro-5-((2-fluoro-4-iodophenyl)amino)-N-(2-hydroxyethoxy)-;
NCIt definition : An orally bioavailable inhibitor of mitogen-activated protein kinase kinase (MAP2K,
MAPK/ERK kinase, or MEK), with potential antineoplastic activity. Upon administration,
tunlametinib selectively binds to and inhibits the activity of MEK, preventing the
activation of MEK-dependent effector proteins and transcription factors, which may
result in the inhibition of growth factor-mediated cell signaling and tumor cell proliferation.
MEK, a threonine/tyrosine kinase, plays a key role in the activation of the RAS/RAF/MEK/ERK
pathway that regulates cell growth. This pathway is often dysregulated in a variety
of tumor cell types through BRAF, KRAS and NRAS mutations.;
UNII : IF25NR1PV3;
CAS number : 1801756-06-8;
Molecule name : HL-085; HL 085;
NCI Metathesaurus CUI : CL1407412;
Origin ID : C173437;
UMLS CUI : C5706578;
Semantic type(s)
- concept_is_in_subset
