Preferred Label : Unecritinib;
NCIt synonyms : ALK/ROS1/Met Inhibitor TQ-B3101;
NCIt definition : An orally available, small molecule inhibitor of the receptor tyrosine kinases anaplastic
lymphoma kinase (ALK), C-ros oncogene 1 (ROS1) and Met (hepatocyte growth factor receptor;
HGFR; c-Met), with potential antineoplastic activity. Upon oral administration,unecritinib
targets, binds to and inhibits the activity of ALK, ROS1 and c-Met, which leads to
the disruption of ALK-, ROS1- and c-Met-mediated signaling and the inhibition of cell
growth in ALK-, ROS1- and c-Met-expressing tumor cells. ALK, ROS1 and c-Met, overexpressed
or mutated in many tumor cell types, play key roles in tumor cell proliferation, survival,
invasion and metastasis.;
UNII : 4T3Z98RR86;
CAS number : 1418026-92-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1418026-92-2
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Molecule name : TQB 3101; TQB-3101;
NCI Metathesaurus CUI : CL1407437;
Origin ID : C173430;
UMLS CUI : C5706682;
Semantic type(s)
- concept_is_in_subset
