Preferred Label : Allogeneic Plasmacytoid Dendritic Cells Expressing Lung Tumor Antigens PDC*lung01;
NCIt synonyms : Therapeutic Cancer Vaccine PDC*lung01; Allogeneic pDCs- expressing Lung Tumor Antigens PDC*lung01;
NCIt definition : An off-the-shelf (OTS) preparation composed of irradiated allogeneic plasmacytoid
dendritic cells (pDCs) loaded with seven immunogenic, human leukocyte antigen (HLA)-A*02:01
serotype-restricted peptides derived from the lung tumor antigens cancer/testis antigen
1 (NY-ESO-1), melanoma antigen A3 (MAGE-A3), MAGE-A4, multi-MAGE, a peptide shared
by multiple MAGE-A proteins, survivin, mucin1 (MUC1) and melanoma antigen recognized
by T-cells 1 (Mart-1; Melan-A), with potential immunostimulating and antineoplastic
activities. Upon administration of the allogeneic pDCs expressing lung tumor antigens
PDC*lung01, the pDCs may activate the immune system to mount a specific cytotoxic
T-lymphocyte (CTL) response against HLA-A*0201 positive lung cancer cells expressing
the TAAs NY-ESO-1, MAGE-A3, MAGEA4, multi-MAGE, survivin, MUC1 and melan-A. The pDCs
are derived from a distinct subset of dendritic cells (DCs) with a plasma cell-like
morphology and express a characteristic set of surface markers and may increase the
anti-tumor immune responses.;
Molecule name : PDC*lung01; PDClung01;
NCI Metathesaurus CUI : CL1407435;
Origin ID : C173427;
UMLS CUI : C5417978;
Semantic type(s)
- concept_is_in_subset
