Preferred Label : Anti-CTLA4 Antibody Fc Fusion Protein KN044;
NCIt synonyms : Anti-CTLA4 Antibody Fusion Protein KN044;
NCIt definition : A recombinant, humanized fusion protein consisting of a cytotoxic T-lymphocyte-associated
antigen 4 (CTLA4; CTLA-4) single domain antibody linked to a Fc domain, with potential
immune checkpoint inhibitory and antineoplastic activities. Upon administration, anti-CTLA4
antibody Fc fusion protein KN044 targets and binds to CTLA4 expressed on T-cells and
inhibits the CTLA4-mediated downregulation of T-cell activation. This leads to a cytotoxic
T-lymphocyte (CTL)-mediated immune response against cancer cells. CTLA4, an inhibitory
receptor and member of the immunoglobulin superfamily (IgSF), plays a key role in
the downregulation of the immune system.;
Molecule name : KN-044; KN 044;
NCI Metathesaurus CUI : CL1407438;
Origin ID : C173422;
UMLS CUI : C5417976;
Semantic type(s)
- concept_is_in_subset
