Preferred Label : Anti-HER2-DM1 ADC B003;
NCIt synonyms : Anti-HER2-DM1 Antibody-drug Conjugate B003; ADC B003; Recombinant Humanized Anti-HER2 Monoclonal Antibody-MCC-DM1 B003;
NCIt definition : An antibody-drug conjugate (ADC) consisting of a recombinant humanized anti-epidermal
growth factor receptor 2 (HER2) monoclonal antibody conjugated to the maytansinoid
DM1 via a nonreducible thioether linkage (MCC), with potential antineoplastic activity.
Upon administration of B003, the anti-HER2 monoclonal antibody moiety targets and
binds to HER2 on tumor cell surfaces; upon internalization, the DM1 moiety is released
and binds to tubulin, thereby disrupting microtubule assembly/disassembly dynamics,
inhibiting cell division and the proliferation of cancer cells that overexpress HER2.;
Molecule name : B-003; B 003;
NCI Metathesaurus CUI : CL1407429;
Origin ID : C173420;
UMLS CUI : C0254939;
Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
