Preferred Label : Quinolonyl-oxazolidinone Antibiotic DNV3837;
NCIt related terms : MCB-3837;
NCIt definition : A prodrug of DNV3681, a small molecule quinolonyl-oxazolidinone antibiotic with activity
against Gram-positive bacteria, including Clostridioides difficile. Upon intravenous
administration, DNV3837 crosses the gastrointestinal barrier to reach the C. difficile
infection site. The active drug DNV3681 may affect four bacterial targets including
DNA-gyrase, topoisomerase IV, protein synthesis and aminoacyl-t-RNA synthetases, which
leads to bacterial cell death. DNV3681 does not have antibacterial activity against
aerobic and anaerobic Gram-negative bacteria, sparing intestinal Bacteroides spp.
that provide colonization resistance in the digestive tract.;
UNII : 1221R21ZRQ;
CAS number : 790704-50-6;
Molecule name : DNV-3837; MCB-3837; DNV 3837; MCB 3837;
NCI Metathesaurus CUI : CL1407230;
Origin ID : C173413;
UMLS CUI : C5417972;
Semantic type(s)
- concept_is_in_subset
