Preferred Label : Ruthenium-based Small Molecule Therapeutic BOLD-100;
NCIt definition : A ruthenium-based, small molecule that selectively inhibits stress-induced upregulation
of GRP78, with potential antineoplastic activity. Although the exact mechanisms(s)
through which this agent exerts its effects have yet to be fully elucidated, upon
administration, BOLD-100 may selectively inhibit stress-induced upregulation of GRP78,
thereby preventing the activation of multiple GRP78-mediated pathways and blocking
GRP78-induced suppression of apoptotic pathways. This may lead to the induction of
tumor cell apoptosis and slow tumor cell proliferation. GRP78, the endoplasmic reticulum
(ER) chaperone and unfolded protein response (UPR) regulator, is overexpressed on
the surface of a variety of cancer cell types. Its expression is associated with increased
tumor cell survival and proliferation, as well as angiogenesis and resistance to chemotherapy.;
Molecule name : BOLD-100; BOLD 100;
NCI Metathesaurus CUI : CL1407205;
Origin ID : C173373;
UMLS CUI : C5417966;
Semantic type(s)
- concept_is_in_subset
