Preferred Label : CD44v6-specific CAR T-cells;
NCIt synonyms : CD44v6 CAR-T Cells; CD44v6-specific CAR Gene-engineered T-cells; 4SCAR-CD44v6 T-cells; Anti-CD44v6 CAR T-cells; 4SCAR-CD44v6 T Cells;
NCIt definition : A preparation of genetically modified T-lymphocytes transduced with a lentiviral vector
encoding a fourth-generation specific chimeric antigen receptor (4SCAR) specific for
CD44 variant domain 6 (CD44v6), with potential immunomodulating and antineoplastic
activities. Upon administration, CD44v6-specific CAR T-cells specifically recognize
and kill CD44v6-expressing tumor cells. CD44, a transmembrane glycoprotein and hyaluronic
acid receptor, is expressed in healthy tissue and overexpressed in numerous cancer
cell types. CD44v6, the isoform containing the variant domain 6 of CD44 gene, plays
a key role in tumor cell invasion, proliferation and metastasis.;
NCI Metathesaurus CUI : CL1407192;
Origin ID : C173368;
UMLS CUI : C5420174;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
