Preferred Label : Personalized and Adjusted Neoantigen Peptide Vaccine PANDA-VAC;
NCIt synonyms : Personalized Neoantigen Peptide Vaccine PANDA-VAC; Personalized Neoantigen Peptide-poly-ICLC Vaccine PANDA-VAC; PANDA-VAC;
NCIt definition : A peptide-based, personalized cancer therapeutic vaccine consisting of up to 8 patient-specific
tumor peptides, which are immunogenic and unique to the patient's tumor and identified
through DNA and RNA sequencing of a patient's tumor cells, combined with the immunostimulant
polyinosinic-polycytidylic acid stabilized with polylysine and carboxymethylcellulose
(poly-ICLC), with potential immunomodulating and antineoplastic activities. Upon administration,
personalized and adjusted neoantigen peptide vaccine PANDA-VAC stimulates the host
immune system to mount a cytotoxic T-lymphocyte (CTL) response against tumor cells
expressing the neoantigens, leading to tumor cell lysis. The adjuvant poly-ICLC is
a ligand for toll-like receptor-3 (TLR3) and induces the release of cytokines which
may help to boost the immune response against the selected neoantigens. The vaccine
may be adjusted after initial therapy according to sequencing data.;
NCI Metathesaurus CUI : CL1407017;
Origin ID : C173152;
UMLS CUI : C5420065;
Semantic type(s)
- concept_is_in_subset
