Preferred Label : SARS-CoV-2 SP modRNA LNP vaccine BNT162a1;
NCIt synonyms : BNT162a1 COVID-19 Vaccine; BNT1162a1 SARS-CoV-2 Vaccine;
NCIt related terms : BNT-162A1;
NCIt definition : A formulation consisting of lipid nanoparticle (LNP) encapsulating nucleoside-modified
messenger RNA (modRNA) encoding the severe acute respiratory syndrome coronavirus-2
(SARS-CoV-2) spike glycoprotein (SP), with potential immunizing and anti-COVID-19
activities. Upon injection of SARS-CoV-2 SP modRNA LNP vaccine BNT162a1, the LNPs
bind to the plasma membrane of nearby cells and release SARS-CoV-2 SP mRNA into the
cell. The mRNA is then translated by the cellular protein translation machinery to
produce SARS-CoV-2 SP. This may stimulate the immune system to induce an antibody
and T-cell-mediated immune response. This may provide active immunization against
SARS-CoV-2 infection. SP, usually found on the surface of SARS-CoV-2, plays an essential
role in the infection pathway of the SARS-CoV-2 virus.;
UNII : N38TVC63NU;
CAS number : 2417899-74-0;
Molecule name : BNT 162a1; BNT-162a1;
NCI Metathesaurus CUI : CL1640890;
Origin ID : C173054;
UMLS CUI : C5398044;
Currated CISMeF NLP mapping
- Semantic type(s)
- concept_is_in_subset
