Preferred Label : Abdavomeran;
NCIt synonyms : BNT162b1 COVID-19 Vaccine; BNT1162b1 SARS-CoV-2 Vaccine;
NCIt definition : A formulation consisting of lipid nanoparticle (LNP) encapsulating nucleoside-modified
messenger RNA (modRNA) encoding the receptor binding domain (RBD) from severe acute
respiratory syndrome coronavirus-2 (SARS-CoV-2) spike glycoprotein (SP), with potential
immunizing and anti-COVID-19 activities. Upon injection of abdavomeran, the LNPs bind
to the plasma membrane of nearby cells and release SARS-CoV-2 SP mRNA into the cell.
The mRNA is then translated by the cellular protein translation machinery to produce
SARS-CoV-2 SP. This may stimulate the immune system to induce an antibody and T-cell-mediated
immune response. This may provide active immunization against SARS-CoV-2 infection.
SP, usually found on the surface of SARS-CoV-2, plays an essential role in the infection
pathway of the SARS-CoV-2 virus.;
UNII : JV8KBX6XZG;
CAS number : 2417899-75-1;
Molecule name : BNT-162b1; BNT 162b1;
NCI Metathesaurus CUI : CL1406824;
Origin ID : C173052;
UMLS CUI : C5446355;
Currated CISMeF NLP mapping
- Semantic type(s)
- concept_is_in_subset
