Preferred Label : SARS-CoV-2 mRNA Vaccine BNT162;
NCIt synonyms : BNT162 COVID-19 Vaccine; BNT162 SARS-CoV-2 Vaccine;
NCIt definition : A formulation consisting of lipid nanoparticle (LNP) encapsulating messenger RNA (mRNA)
encoding the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) spike glycoprotein
(SP), with potential immunizing and anti-COVID-19 activities. Upon injection, the
LNPs bind to the plasma membrane of nearby cells and release SARS-CoV-2 SP mRNA into
the cell. The mRNA is then translated by the cellular protein translation machinery
to produce SARS-CoV-2 SP. This may stimulate the immune system to induce an antibody
and T-cell-mediated immune response. This may provide active immunization against
SARS-CoV-2 infection. SP, usually found on the surface of SARS-CoV-2, plays an essential
role in the infection pathway of the SARS-CoV-2 virus.;
Molecule name : BNT-162; BNT 162;
NCI Metathesaurus CUI : CL1406793;
Origin ID : C173020;
UMLS CUI : C5417954;
Semantic type(s)
- concept_is_in_subset
