Preferred Label : Engineered Red Blood Cells Co-expressing 4-1BBL and IL-15TP RTX-240;
NCIt synonyms : Allogeneic Red Cells Expressing 4-1BBL and IL-15TP; Engineered RBCs Co-expressing 4-1BBL and IL-15TP RTX-240;
NCIt definition : A preparation of allogeneic, off-the-shelf (OTS) red blood cells (RBCs) engineered
to express both the co-stimulatory molecule tumor necrosis factor ligand superfamily
(TNFSF) member 9 (TNFSF9; 4-1BBL) and a fusion protein composed of the trans-presented
cytokine interleukin (IL)-15/IL-15-receptor alpha (IL-15Ra) (IL-15TP) with potential
modulating and antineoplastic activities. CD34 hematopoietic precursor cells (HPC)
are collected by apheresis from a healthy O negative donor, purified, and engineered
with a lentiviral vector to express 4-1BBL and IL-15TP. The cells are then further
expanded and differentiated until the nucleus is ejected, resulting in a mature reticulocyte.
Upon administration of the engineered red blood cells co-expressing 4-1BBL and IL-15TP
RTX-240, the RBCs express both 4-1BBL and IL-15TP on their cell surfaces. 4-1BBL and
IL-15TP bind to and subsequently induce the proliferation and activation of natural
killer (NK) cells and T-cells. This enhances the secretion of cytokine interferon-gamma
(IFN-g) and results in the induction of an anti-tumor immune response.;
Molecule name : RTX-240; RTX 240;
NCI Metathesaurus CUI : CL1406781;
Origin ID : C172990;
UMLS CUI : C5417953;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
