Preferred Label : Gorilla-derived Adenovirus-expressing HPV-16/18 E6/E7 Vaccine;
NCIt synonyms : HPV Vaccine PRGN-2009; Adenovirus Encoding Recombinant Human Endostatin;
NCIt definition : An off-the-shelf (OTS) cancer vaccine comprised of a genetically engineered, replication-deficient
gorilla-derived adenovirus encoding human papillomavirus (HPV) types 16 and 18 E6/E7
antigens, with potential immunostimulating and antineoplastic activities. Upon administration
of gorilla-derived adenovirus expressing HPV-16/18 E6/E7 vaccine PRGN-2009, the adenovirus
infects and expresses the HPV-16/18 E6/E7 proteins. The expressed proteins stimulate
the host immune system to produce antigen-specific neutralizing antibodies and to
mount a cytotoxic T-lymphocyte (CTL) response against tumor cells expressing HPV-16/18
E6/E7 antigens, thereby inducing tumor cell lysis. HPV oncoproteins play a key role
in the development of cervical intraepithelial neoplasia (CIN) and cervical carcinoma.;
Molecule name : PRGN 2009; PRGN-2009;
NCI Metathesaurus CUI : CL1406936;
Origin ID : C172914;
UMLS CUI : C5419951;
Semantic type(s)
- concept_is_in_subset
- has_target
