Preferred Label : Anti-CD7 CAR T-cells;
NCIt synonyms : CD7 CAR T-cells; Anti-CD7 CAR T-lymphocytes;
NCIt definition : A preparation of T-lymphocytes that have been genetically engineered to express a
chimeric antigen receptor (CAR) directed against the tumor-associated antigen (TAA)
CD7, with potential immunostimulating and antineoplastic activities. Upon administration,
the anti-CD7 CAR T-cells specifically recognize and bind to CD7-expressing tumor cells,
resulting in specific T-cell-mediated tumor cell lysis. CD7 is a transmembrane glycoprotein
expressed by T-cells and natural killer (NK) cells and their precursors. It is expressed
in the majority of lymphoblastic T-cell leukemias and lymphomas and in a subset of
peripheral T-cell lymphomas.;
NCI Metathesaurus CUI : CL1406851;
Origin ID : C172817;
UMLS CUI : C5419877;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
