Preferred Label : Genetically Modified SARS-CoV-2 Spike Protein-encoding Bifidobacterium longum DNA
Vaccine;
NCIt synonyms : Genetically Modified SARS-CoV-2 S Protein-encoding Bifidobacterium longum DNA Vaccine; bacTRL-Spike;
NCIt definition : A live, genetically modified probiotic bacteria Bifidobacterium longum (B. longum)
engineered to deliver plasmids containing synthetic DNA encoding SARS-CoV-2 spike
(S) protein, with potential immunizing activity against SARS-CoV-2. Upon oral administration
of genetically modified SARS-CoV-2 S protein-encoding B. longum DNA vaccine, the bacteria
colonize the gut, bind to intestinal epithelial cells, replicate and deliver plasmids
containing synthetic DNA encoding the SARS-CoV-2 S protein, and the cells produce
the SARS-CoV-2 S protein. This may activate both humoral and cellular immune responses
which may result in protection against SARS-CoV-2 infection.;
NCI Metathesaurus CUI : CL1406596;
Origin ID : C172745;
UMLS CUI : C5416823;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- concept_is_in_subset
