NCIt definition : A humanized monoclonal antibody directed against the pro-inflammatory cytokine interleukin-6
(IL-6), with potential immunomodulating and anti-inflammatory activities. Upon administration,
olokizumab targets, binds to and blocks the activity of IL-6, which may inhibit the
binding of IL-6 to its receptor interleukin-6 receptor (IL-6R). This may inhibit the
IL-6/IL-6R-mediated signal transduction pathway and the associated inflammatory response.;