NCIt definition : A humanized immunoglobulin (Ig) G1 monoclonal antibody against the human cytokine
granulocyte macrophage colony-stimulating factor (GM-CSF), with potential anti-inflammatory
and immunomodulating activities. Upon administration, plonmarlimab binds to and neutralizes
GM-CSF. This prevents GM-CSF binding to the GM-CSF receptor and prevents GM-CSF-mediated
signaling, thereby inhibiting inflammatory responses mediated by macrophages, neutrophils,
and dendritic cells and reducing inflammation and tissue damage. GM-CSF plays a key
role in the differentiation and proliferation of monocytes, macrophages and granulocytes.
Elevated levels of GM-CSF are associated with certain autoimmune diseases, inflammatory
diseases, and cancers.;
UNII : M1K0A3X96W;
CAS number : 2377482-36-3;
Molecule name : TJM-2; TJ 003234; TJM 2; TJ-003234;