Plonmarlimab - CISMeF

Preferred Label : Plonmarlimab;

NCIt synonyms : Anti-GM-CSF Monoclonal Antibody TJ-003234;

NCIt definition : A humanized immunoglobulin (Ig) G1 monoclonal antibody against the human cytokine granulocyte macrophage colony-stimulating factor (GM-CSF), with potential anti-inflammatory and immunomodulating activities. Upon administration, plonmarlimab binds to and neutralizes GM-CSF. This prevents GM-CSF binding to the GM-CSF receptor and prevents GM-CSF-mediated signaling, thereby inhibiting inflammatory responses mediated by macrophages, neutrophils, and dendritic cells and reducing inflammation and tissue damage. GM-CSF plays a key role in the differentiation and proliferation of monocytes, macrophages and granulocytes. Elevated levels of GM-CSF are associated with certain autoimmune diseases, inflammatory diseases, and cancers.;

UNII : M1K0A3X96W;

CAS number : 2377482-36-3;

Molecule name : TJM-2; TJ 003234; TJM 2; TJ-003234;

NCI Metathesaurus CUI : CL1406735;

Details

Origin ID

C172653;

UMLS CUI

C5544543;

Currated CISMeF NLP mapping
- plonmarlimab [MeSH concept]
- plonmarlimab [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- plonmarlimab [MeSH Supplementary Concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients