Preferred Label : Vidofludimus Calcium Anhydrous;
NCIt synonyms : Vidofludimus Calcium;
NCIt definition : The calcium salt form of vidofludimus, an orally bioavailable inhibitor of dihydroorotate
dehydrogenase (DHODH), with potential anti-inflammatory, immunomodulating and anti-viral
activities. Upon administration, vidofludimus specifically targets, binds to and prevents
the activation of DHODH. This prevents the fourth enzymatic step in de novo pyrimidine
synthesis, leading to inhibition of transcriptional elongation, cell cycle arrest,
and apoptosis in activated lymphocytes. DHODH inhibition also leads to metabolic stress
in activated lymphocytes and inhibition of the release of proinflammatory cytokines
including interleukin (IL)-17 (IL-17A and IL-17F) and interferon-gamma (IFNg), thereby
reducing inflammation. In addition, DHODH inhibition may lead to host-based anti-viral
activity against many viruses. DHODH, a mitochondrial enzyme that catalyzes the conversion
of dihydroorotate (DHO) to orotate, is a key enzyme in pyrimidine de novo biosynthesis.
Metabolically highly activated and rapidly proliferating lymphocytes and various virus
infected cells require de novo synthesis to meet their needs for pyrimidines.;
UNII : FW5VY7926X;
InChIKey : KWSJBFAXOPFZSO-UHFFFAOYSA-L;
CAS number : 1354012-90-0;
Molecule name : IMU-838; IMU 838;
NCI Metathesaurus CUI : CL1406732;
Origin ID : C172652;
UMLS CUI : C5419765;
Semantic type(s)
- concept_is_in_subset
- has_free_acid_or_base_form
- is_salt_form_of
