Meplazumab - CISMeF

Preferred Label : Meplazumab;

NCIt synonyms : Ketantin;

NCIt definition : A humanized immunoglobulin G2 (IgG2) monoclonal antibody directed against CD147 (basigin; BSG; extracellular matrix metalloproteinase inducer; EMMPRIN), with potential immunomodulating activity. Upon administration, meplazumab targets, binds to and inhibits the activity of CD147. This may prevent the binding of the spike protein (SP) of SARS-CoV-2 to CD147 on human host cells. This may prevent SARS-CoV-2's host cell entry through CD147-mediated transport and prevent host cell invasion. This may block SARS-CoV-2 infection. In addition, preventing viral invasion of progenitor/stem cells may enhance lung repair and suppress inflammation. CD147, a highly glycosylated transmembrane protein of the immunoglobulin superfamily expressed on host-cells, including red blood cells (RBCs), T-cells, and stem/progenitor cells, may play a key role in host invasion by SARS-CoV-2.;

UNII : 0EL07E29VQ;

Molecule name : PMZ-201501;

NCI Metathesaurus CUI : CL1406749;

Details

Origin ID

C172638;

UMLS CUI

C5419754;

Automatic exact mappings (from CISMeF team)
- Ketantin [MeSH concept]
- meplazumab [MeSH concept]
Currated CISMeF NLP mapping
- meplazumab [COVID-19 Thesaurus concept]
- meplazumab [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- meplazumab [MeSH Supplementary Concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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