Preferred Label : Gimsilumab;
NCIt synonyms : Immunoglobulin G1, Anti-(Human Granulocyte-Macrophage Colony-Stimulating Factor) (Human
Monoclonal Morab-022 Heavy Chain), Disulfide with Human Monoclonal Morab-022 Kappa-Chain,
Dimer;
NCIt definition : A human immunoglobulin G1 (IgG1) monoclonal antibody directed against the myeloid
cell growth factor and inflammatory mediator granulocyte-macrophage colony-stimulating
factor (GM-CSF), with potential immunomodulating activity. Upon administration, gimsilumab
targets, binds to and neutralizes GM-CSF. This prevents the binding of GM-CSF to its
targeted inflammatory cells, and prevents proliferation and activation of various
immune cells. This prevents the release of cytokines and B- and T-cell-mediated immune
responses. GM-CSF, a monomeric glycoprotein functioning as a cytokine, promotes the
proliferation and activation of macrophages and neutrophils. GM-CSF levels are elevated
in certain immune-mediated diseases. It increases the production of pro-inflammatory
mediators, such as cytokines, chemokines and proteases.;
UNII : 8961SFA7R3;
CAS number : 1648796-29-5;
Molecule name : MORAb-022;
NCI Metathesaurus CUI : CL1406702;
Origin ID : C172615;
UMLS CUI : C5139894;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
