Tyrosine Kinase Inhibitor SU5402

Preferred Label : Tyrosine Kinase Inhibitor SU5402;

NCIt synonyms : 3-[(3-(2-carboxyethyl)-4-methylpyrrol-2-yl)methylene]-2-indolinone; SU5402;

NCIt definition : An indolinone-based small molecule selective tyrosine kinase inhibitor with potential antineoplastic activity. SU5402 blocks the activities of vascular endothelial growth factor receptors (VEGFR) and fibroblast growth factor 1 (FGFR1) via competing with ATP for the specific binding site within the catalytic domain of these receptors. This agent was shown to inhibit cell growth, decrease cell viability in dose-dependent manner, and induce apoptosis.;

Molecule name : SU 5402;

ChEBI ID : CHEBI:63449;

Details

Origin ID

C1725;

UMLS CUI

C0538431;

Automatic exact mappings (from CISMeF team)
- SU 5402 [MeSH concept]
- SU 5402 [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- SU 5402 [MeSH concept]
- SU 5402 [MeSH Supplementary Concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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