Preferred Label : Anti-integrin Beta-6/MMAE Antibody-drug Conjugate SGN-B6A;
NCIt synonyms : Anti-integrin Beta-6 Antibody-drug Conjugate SGN-B6A; Anti-integrin Beta-6-MMAE ADC SGN-B6A; Anti-integrin Beta-6/MMAE ADC SGN-B6A;
NCIt definition : An antibody-drug conjugate (ADC) composed of a humanized antibody targeting integrin
beta-6 and conjugated to the microtubule-disrupting cytotoxic agent monomethyl auristatin
E (MMAE), with potential antineoplastic activity. Upon administration, the antibody
moiety of anti-integrin beta-6/MMAE ADC SGN-B6A targets and binds to integrin beta-6
on the surface of tumor cells. Following internalization of SGN-B6A and release of
MMAE, MMAE targets and binds to tubulin, and inhibits microtubule polymerization.
This results in G2/M phase cell cycle arrest and apoptosis in integrin beta-6-expressing
tumor cells. Integrin beta-6 is a subunit of integrin alpha-V beta-6 (aVb6). Integrin
aVb6, a cell adhesion and signaling receptor, is upregulated in certain cancer cell
types and has been associated with increased proliferation, migration and invasion
of tumor cells.;
Molecule name : SGN B6A; SGN-B6A;
NCI Metathesaurus CUI : CL1406348;
Origin ID : C172391;
UMLS CUI : C5417916;
Semantic type(s)
- concept_is_in_subset
- has_target
