Preferred Label : ROBO1-targeted BiCAR-NKT Cells;
NCIt synonyms : Anti-ROBO1 BiCAR-NK/T Cells; ROBO1 CAR-NK/T Cells; ROBO1-targeted Bi-CAR-NK/T Cells;
NCIt definition : A preparation of natural killer T (NKT) cells engineered to express a chimeric antigen
receptor (CAR) specific for roundabout homolog 1 (ROBO1, Robo1), with potential immunostimulating
and antineoplastic activities. Upon administration, the ROBO1-targeted BiCAR-NK/T
cells target and bind to ROBO1 expressed on the surface of tumor cells. This induces
selective toxicity in ROBO1-expressing tumor cells. ROBO1, a member of the axon guidance
receptor family, is often overexpressed in a variety of tumor types. It is involved
in axon guidance, cell proliferation, cell motility and angiogenesis.;
NCI Metathesaurus CUI : CL1406507;
Origin ID : C172380;
UMLS CUI : C5419626;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
