Preferred Label : Anti-CD19 Antibody-T-cell Receptor-expressing T-cells ET019003;
NCIt synonyms : CD19-targeted T-cells ET019003; Anti-CD19 T-cells ET019003; ET019003-T Cells; Anti-CD19-TCR T-cells ET019003; Anti-CD19 AbTCR-expressing T-cells ET019003;
NCIt definition : A preparation of T-lymphocytes that have been engineered by incorporating an as of
yet undisclosed co-stimulatory molecule into T-cells expressing an anti-CD19 antibody
T-cell receptor (AbTCR) structure (ET190L1), with potential immunostimulating and
antineoplastic activities. Upon administration, anti-CD19 AbTCR-expressing T-cells
ET019003 targets and binds to CD19-expressing tumor cells. This results in cytotoxic
T-lymphocyte (CTL)-mediated elimination of CD19-positive tumor cells. The binding
to CD19-expressing tumor cells may also activate the undisclosed costimulatory domain,
leading to further T-cell proliferation. CD19 antigen is a B-cell specific cell surface
antigen overexpressed in B-cell lineage malignancies. ET019003 is able to match the
anticancer activity of chimeric antigen receptor (CAR) T-cells, while they are less
likely to stimulate cytokine release syndrome (CRS) and less likely to cause cytokine-related
toxicities.;
Molecule name : ET-019003; ET 019003;
NCI Metathesaurus CUI : CL1406089;
Origin ID : C172202;
UMLS CUI : C5417908;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
