Preferred Label : Anti-HER2 Monoclonal Antibody HLX22;
NCIt definition : A humanized immunoglobulin (lg) G1 monoclonal antibody directed against the human
epidermal growth factor receptor 2 (HER2), with potential immunomodulating and antineoplastic
activity. Upon administration, anti-HER2 monoclonal antibody HLX22 targets and binds
to HER2 on tumor cell surface. This may induce a cytotoxic T-lymphocyte (CTL) response
as well as an antibody-dependent cell-mediated cytotoxicity (ADCC) against tumor cells
that overexpress HER2. HER2, a tyrosine kinase receptor, is overexpressed by many
cancer cell types.;
Molecule name : HLX-22; HLX 22;
NCI Metathesaurus CUI : CL1406092;
Origin ID : C172198;
UMLS CUI : C5417907;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
