Preferred Label : Porcupine Inhibitor XNW7201;
NCIt synonyms : PORCN Inhibitor XNW7201;
NCIt definition : An orally available inhibitor of porcupine (PORCN), with potential antineoplastic
activity. Upon oral administration, PORCN inhibitor XNW7201 targets, binds to and
inhibits PORCN in the endoplasmic reticulum (ER), which blocks post-translational
acylation of Wnt ligands and inhibits their secretion. This prevents the activation
of Wnt ligands, interferes with Wnt-mediated signaling, and inhibits cell growth in
Wnt-driven tumors. PORCN, a membrane-bound O-acyltransferase (MBOAT), is required
for the palmitoylation of Wnt ligands, and plays a key role in Wnt ligand secretion
and activity. Wnt signaling is dysregulated in a variety of cancers and plays a key
role in cancer cell survival.;
Molecule name : XNW-7201; XNW 7201;
NCI Metathesaurus CUI : CL1406288;
Origin ID : C172189;
UMLS CUI : C5417897;
Semantic type(s)
- concept_is_in_subset
