Preferred Label : Multisystem Inflammatory Syndrome in Children;
NCIt synonyms : MISC; Pediatric Inflammatory Multisystem Syndrome; Pediatric Multi-System Inflammatory Syndrome Potentially Associated with COVID-19; PIMS; PMIS; COVID-19-Related Pediatric Inflammatory Multisystem Syndrome; Multisystem Inflammatory Syndrome in Children Associated with COVID-19; Pediatric Multisystem Inflammatory Syndrome; MIS-C;
NCIt related terms : Multisystem inflammatory syndrome in children (MIS-C);
NCIt definition : A rare syndrome temporally associated with COVID-19 in children, marked by persistent
fever, inflammation (neutrophilia, elevated C-reactive protein (CRP), and lymphopenia),
poor function in one or more organs, and other specific clinical and laboratory features
not attributable to other infections. The characteristics of this syndrome appear
to be similar to toxic shock syndrome and Kawasaki disease. The following variable
signs and symptoms have been most commonly reported to date: coagulopathy, cardiac
dysfunction, diarrhea, abdominal distension, other GI symptoms (with some children
having positive stool tests for SARS-CoV-2), and acute kidney injury. Respiratory
symptoms are not always a prominent feature in these cases.;
Alternative definition : ACC/AHA: The occurrence of fever, laboratory evidence of inflammation, and evidence
of clinically severe illness requiring hospitalization with multisystem (greater than
or equal to 2) organ involvement AND No plausible alternative diagnoses AND Positive
for current or recent SARS-CoV-2 infection by RT-PCR, serology, or antigen test OR
exposure to a suspected or confirmed COVID-19 case within 4 wk prior to symptom onset
in an individual aged less than 21 y;
NCI Metathesaurus CUI : CL1406225;
Origin ID : C172127;
UMLS CUI : C5391534;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
