Preferred Label : Powdered Mixed Berry Extract Supplement;
NCIt synonyms : Powdered Berry Extracts Blend; Powdered Natural Berry Extracts; Powdered Berry Extracts; Powdered NBE;
NCIt definition : A dietary powder supplement consisting of a mixture of various, as of yet not fully
elucidated, berries, with potential antineoplastic and anti-angiogenic activities.
As berries are rich in phytonutrients, such as anthocyanins, flavonols, ellagitannins,
galltannins, proanthocyanidins, and phenolic acids, the antineoplastic effects of
the powdered mixed berry extract supplement on cancer cells may be attributable to
the phytonutrients' antioxidant and pro-apoptotic activities. Upon administration
of the powdered mixed berry extract supplement, the phytochemicals in the berries
may work together to reduce angiogenesis, tumor growth and tumor development. Specifically,
various phytochemicals may inhibit the multidrug resistance protein-1 (MRP-1), which
results in the accumulation of cellular oxidized glutathione (GSSG). Elevated intracellular
levels of GSSG causes an increase in oxidative stress. This triggers the induction
of oxidative stress-mediated apoptosis and may inhibit tumor and endothelial cell
proliferation. MRP-1, overexpressed in many different types of cancer, plays a key
role in the efflux of GSSG and thus the maintenance of oxidative homeostasis and survival
in tumor cells.;
Drug name : PediaBerry;
NCI Metathesaurus CUI : CL1406213;
Origin ID : C172110;
UMLS CUI : C5419455;
Semantic type(s)
- Food [UMLS semantic type]
- concept_is_in_subset
