Preferred Label : Anti-TIM3 Monoclonal Antibody SHR-1702;
NCIt definition : A monoclonal antibody against the inhibitory T-cell receptor, T-cell immunoglobulin
and mucin domain-containing protein 3 (TIM-3; TIM3; hepatitis A virus cellular receptor
2; HAVCR2), with potential immune checkpoint inhibitory and antineoplastic activities.
Upon administration, anti-TIM3 monoclonal antibody SHR-1702 targets and binds to TIM-3
expressed on certain T-cells, including tumor infiltrating lymphocytes (TILs). This
abrogates T-cell inhibition, activates antigen-specific T-lymphocytes and enhances
cytotoxic T-cell-mediated tumor cell lysis, which results in a reduction in tumor
growth. TIM-3, a transmembrane protein and immune checkpoint receptor, is associated
with tumor-mediated immune suppression.;
Molecule name : SHR-1702; SHR 1702;
NCI Metathesaurus CUI : CL1406215;
Origin ID : C172108;
UMLS CUI : C5417894;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
