Preferred Label : Oncolytic Type 2 Herpes Simplex Virus Expressing Granulocyte Macrophage Colony-Stimulating
Factor OH2;
NCIt synonyms : HG52/ICP34.5-/ICP47- HSV-2-expressing GM-CSF OH2; Oncolytic HSV-2 Expressing GM-CSF OH2; oHSV-2-expressing GM-CSF OH2;
NCIt definition : A genetically engineered, ICP34.5- and ICP47-deleted oncolytic human herpes simplex
type-2 virus (HSV-2), derived from the HG52 strain, encoding the immunostimulating
factor cytokine granulocyte-macrophage colony stimulating factor (GM-CSF), with potential
immunostimulating and antineoplastic activities. Upon administration, the oncolytic
HSV-2 expressing GM-CSF OH2 selectively infects and replicates in tumor cells, thereby
inducing tumor cell lysis. In addition, GM-CSF attracts dendritic cells (DCs) and
may stimulate a cytotoxic T cell response against tumor cells, which results in immune-mediated
tumor cell death. Deletion of the gene encoding for ICP34.5 provides tumor selectivity
and prevents replication in healthy cells. As ICP47 blocks antigen presentation in
HSV-infected cells, deletion of this gene may induce a more potent antitumor immune
response in the tumor cells. Additionally, deletion of ICP47 causes increased expression
of the HSV US11 gene and allows US11 to be expressed as an immediate early and not
a late gene. This further enhances the degree of viral replication and oncolysis of
tumor cells. Mutation of the ICP6 gene, which encodes the large subunit of the viral
ribonucleotide reductase, in the viral vector also enhances selective replication
in tumor cells.;
Molecule name : OH 2; OH-2;
NCI Metathesaurus CUI : CL1406217;
Origin ID : C172106;
UMLS CUI : C5417892;
Semantic type(s)
- concept_is_in_subset
