Preferred Label : Oxaliplatin Eluting Beads;
NCIt synonyms : CalliSpheres Drug-Eluting Beads with Oxaliplatin; DEB with Oxaliplatin; Drug-Eluting Beads with Oxaliplatin; Deboxa;
NCIt definition : A formulation of drug-eluting beads (DEB) consisting of polymeric microbeads impregnated
with the organoplatinum complex and alkylating agent oxaliplatin, with potential antineoplastic
activity. The beads consist of polyvinyl alcohol (PVA) microspheres modified with
sulfonic acid groups and loaded with oxaliplatin. During transarterial chemoembolization
(TACE) in the hepatic artery, the oxaliplatin eluting beads occlude tumor blood vessels
that feed the tumor and induce ischemic necrosis of tumor tissue due to mechanical
blockage of the tumor vasculature. The beads release cytotoxic oxaliplatin locally,
which may result in oxaliplatin-mediated inhibition of tumor cell proliferation through
formation of both inter- and intra-strand platinum-DNA crosslinks, and the inhibition
of DNA replication.;
NCI Metathesaurus CUI : CL1406222;
Origin ID : C172098;
UMLS CUI : C5419452;
Semantic type(s)
- concept_is_in_subset
