Preferred Label : Anti-TROP2 Antibody-drug Conjugate BAT8003;
NCIt synonyms : ADC BAT8003; Anti-TROP2 ADC BAT8003; Anti-Trop-2 Antibody-drug Conjugate BAT8003;
NCIt definition : An antibody-drug conjugate (ADC) composed of a monoclonal antibody against tumor-associated
antigen (TAA) trophoblast cell surface protein 2 (trophoblast antigen 2; calcium signal
transducer 2; TROP2; TROP-2; TACSTD2; GA733-1; M1S1) conjugated via an uncleavable
linker to an as of yet undisclosed maytansine derivative toxin, with potential antineoplastic
activity. Upon administration of the anti-TROP2 ADC BAT8003, the anti-TROP2 antibody
targets and binds to TROP2 expressed on tumor cells. Upon cellular uptake, the cytotoxic
maytansine derivative binds to tubulin, thereby affecting microtubule assembly and
disassembly dynamics. This inhibits tumor cell proliferation of TROP2-expressing tumor
cells. TROP2 is a transmembrane protein overexpressed in various tumors. Its expression
is associated with enhanced tumor aggressiveness, metastasis, drug resistance and
increased tumor cell survival.;
Molecule name : BAT 8003; BAT-8003;
NCI Metathesaurus CUI : CL1406188;
Origin ID : C172060;
UMLS CUI : C5417885;
Semantic type(s)
- concept_is_in_subset
