Preferred Label : Fluorine F 18-Al-NOTA-octreotide;
NCIt synonyms : Al18F-OC; Fluorine F18 IMP-466; Al18F-1,4,7-triazacyclononane-1,4,7-triacetate-octreotide; 18F-AlF-NOTA-octreotide; Al18F-NOTA-octreotide; Fluorine F18 NOTA Octreotide; 18F-IMP-466; Fluorine F 18-AIF-NOTA-octreotide;
NCIt definition : A radioconjugate consisting of octreotide linked to the radionuclide fluorine F 18
(18F), by the macrocyclic chelating agent, 1,4,7-triazacyclononane-1,4,7-triacetate
(NOTA), through a method that first couples 18F to aluminum (Al), with potential imaging
activity using positron emission tomography (PET). Upon administration of fluorine
F 18-Al-NOTA-octreotide, the octreotide moiety targets and binds to somatostatin receptors
(SSTRs) on SSTR-expressing tumor cells. This allows for visualization of SSTR-expressing
tumor cells upon PET imaging. SSTRs have been shown to be present in large numbers
on neuroendocrine tumors (NETs) and their metastases, while most other normal tissues
express low levels of SSTRs.;
NCI Metathesaurus CUI : CL1406189;
Origin ID : C172059;
UMLS CUI : C5419438;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
