Preferred Label : CYP11A1 Inhibitor ODM-209;
NCIt definition : An orally bioavailable inhibitor of the enzyme cytochrome 450 side-chain cleavage
(scc)(CYP11A1), with potential antineoplastic activity. Upon oral administration,
CYP11A1 inhibitor ODM-209 targets, binds to and inhibits the activity of CYP11A1.
This prevents the synthesis of all steroid hormones and their precursors. This may
inhibit the proliferation of hormone-positive tumor cells. CYP11A1, a mitochondrial
enzyme, catalyzes the conversion of cholesterol to pregnenolone (Preg), which is the
first rate-limiting step in steroid hormone biosynthesis.;
Molecule name : ODM-209; ODM 209;
NCI Metathesaurus CUI : CL1406195;
Origin ID : C172052;
UMLS CUI : C5417883;
Semantic type(s)
- concept_is_in_subset
