Preferred Label : Aviptadil;
NCIt synonyms : L-Histidyl-L-seryl-L-aspartyl-L-alanyl-L-valyl-L-phenylalanyl-L-threonyl-L-aspartyl-L-asparaginyl-L-tyrosyl-L-threonyl-L-arginyl-L-leucyl-L-arginyl-L-lysyl-L-glutaminyl-L-methionyl-L-alanyl-L-valyl-L-lysyl-L-lysyl-L-tyrosyl-L-leucyl-L-asparaginyl-L-seryl-L-isoleucyl-L-leucyl-L-asparagine;
NCIt definition : A synthetic form of vasoactive intestinal polypeptide (VIP), with potential anti-cytokine,
anti-inflammatory, and immune-regulatory activities. Upon administration, aviptadil
mimics endogenous VIP. In the lungs, aviptadil may prevent N-Methyl-D-aspartic acid
(NMDA)-induced caspase-3 activation, inhibits the production of certain pro-inflammatory
mediators, such as interleukin-6 (IL-6) and tumor-necrosis factor-alpha (TNFa), and
may protect the lungs against a cytokine storm and inflammation. As cytokines cause
the air sacs of the lungs to fill with water, making the sacs impermeable to oxygen,
aviptadil may protect against pulmonary edema, and restores the barrier function at
the endothelial/alveolar interface. This may improve blood oxygenation, respiratory
distress, and prevent lung injury. VIP is a naturally synthesized peptide hormone
that is highly concentrated in the lungs.;
UNII : A67JUW790C;
CAS number : 40077-57-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 40077-57-4
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G-SRS /a ;
Drug name : Invicorp;
Molecule name : RLF-100;
Origin ID : C171932;
UMLS CUI : C1098515;
Currated CISMeF NLP mapping
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
