NCIt definition : A radioconjugate composed of the paired helical filament (PHF) tau binding agent flortaucipir,
a benzimidazole pyrimidine derivative, conjugated to the radioisotope fluorine F 18,
with potential tau positron emission tomography (PET) imaging activity. Upon administration,
flortaucipir F-18 targets and binds to PHF-tau in the brain, which allows PET imaging
of PHF-tau and analysis of phosphorylated PHF-tau aggregates (neurofibrillary tangles).
Increased levels of PHF-tau and neurofibrillary tangles are correlated with the cognitive
decline seen in neurodegenerative diseases, such as dementia, Alzheimer's disease
(AD) and chemotherapy-induced cognitive impairment (CICI).;