Flortaucipir F-18

Preferred Label : Flortaucipir F-18;

NCIt synonyms : Fluorine-18 Labeled 7-(6-Fluoropyridin-3-yl)-5H-pyrido[4,3-b]indole; [F18]T807; Fluorine F18 T807; [(18)F]T807; [18F]T807; 18F-AV-1451; F 18 T807;

NCIt definition : A radioconjugate composed of the paired helical filament (PHF) tau binding agent flortaucipir, a benzimidazole pyrimidine derivative, conjugated to the radioisotope fluorine F 18, with potential tau positron emission tomography (PET) imaging activity. Upon administration, flortaucipir F-18 targets and binds to PHF-tau in the brain, which allows PET imaging of PHF-tau and analysis of phosphorylated PHF-tau aggregates (neurofibrillary tangles). Increased levels of PHF-tau and neurofibrillary tangles are correlated with the cognitive decline seen in neurodegenerative diseases, such as dementia, Alzheimer's disease (AD) and chemotherapy-induced cognitive impairment (CICI).;

UNII : T1JP1KYU9O;

InChIKey : GETAAWDSFUCLBS-SJPDSGJFSA-N;

CAS number : 1522051-90-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1522051-90-6 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

NCI Metathesaurus CUI : CL1406084;

Details

Origin ID

C171887;

UMLS CUI

C4742689;

Automatic exact mappings (from CISMeF team)
- 7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole [MeSH Supplementary Concept]
Currated CISMeF NLP mapping
- Flortaucipir (18-F) (substance) [SNOMED CT concept]
Semantic type(s)
- Indicator, Reagent, or Diagnostic Aid [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
UMLS correspondences (same concept)
- Flortaucipir (18-F) (substance) [SNOMED CT concept]
- Product containing flortaucipir (18-F) (medicinal product) [SNOMED CT concept]
- flortaucipir (18F) [ATC Code]
Validated automatic mappings to BTNT
- flortaucipir (18F) [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_target
- Microtubule-Associated Protein Tau [NCIt concept]

Keyword's position in hierarchy(ies) :

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