" /> Flortaucipir F-18 - CISMeF





Preferred Label : Flortaucipir F-18;

NCIt synonyms : Fluorine-18 Labeled 7-(6-Fluoropyridin-3-yl)-5H-pyrido[4,3-b]indole; [F18]T807; Fluorine F18 T807; [(18)F]T807; [18F]T807; 18F-AV-1451; F 18 T807;

NCIt definition : A radioconjugate composed of the paired helical filament (PHF) tau binding agent flortaucipir, a benzimidazole pyrimidine derivative, conjugated to the radioisotope fluorine F 18, with potential tau positron emission tomography (PET) imaging activity. Upon administration, flortaucipir F-18 targets and binds to PHF-tau in the brain, which allows PET imaging of PHF-tau and analysis of phosphorylated PHF-tau aggregates (neurofibrillary tangles). Increased levels of PHF-tau and neurofibrillary tangles are correlated with the cognitive decline seen in neurodegenerative diseases, such as dementia, Alzheimer's disease (AD) and chemotherapy-induced cognitive impairment (CICI).;

UNII : T1JP1KYU9O;

InChIKey : GETAAWDSFUCLBS-SJPDSGJFSA-N;

CAS number : 1522051-90-6;

NCI Metathesaurus CUI : CL1406084;

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28/05/2025


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