Preferred Label : Florbenazine F-18;
NCIt synonyms : (2R,3R,11bR)-9-(3-18F-fluoropropoxy)-3-isobutyl-10-methoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-2-ol; Fluorine F 18-AV-133; 18F-FP-DTBZ; 9-[18F]Fluoropropyl-( )-dihydrotetrabenazine; 18F-AV-133; 18F-FP-( )-DTBZ;
NCIt definition : A radioconjugate composed of the vesicular monoamine transporter 2 (VMAT2) targeting
agent florbenazine , a dihydrotetrabenazine analog, labeled with the positron-emitting
isotope fluorine F 18, that can potentially be used as a tracer using positron emitting
tomography (PET) imaging. Upon administration , florbenazine F-18 binds to VMATs expressed
on monoamine neurons and pancreatic beta-cells within the islets of Langerhans. Upon
PET imaging, VMAT2-expressing cells can be detected and the level of functional monoamine
neurons can be assessed, which can be used in the diagnosis of neurodegenerative diseases.
In addition, this radiotracer can be used to assess the function of pancreatic beta-cells.
VMAT2, a transporter that loads monoamine neurotransmitters into secretory vesicles,
is expressed on biogenic amine-containing neurons in the central nervous system (CNS)
and pancreatic beta cells.;
UNII : KM31LBX59H;
InChIKey : GNKGXQHHUUEYQV-WTHAECTESA-N;
CAS number : 956903-29-0;
NCI Metathesaurus CUI : CL1406056;
Origin ID : C171883;
UMLS CUI : C3501345;
Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
