Preferred Label : Borofalan (10B);
NCIt synonyms : Boron B 10-condensed Boronophenylalanine; Boronophenylalanine B-10; Boron B 10 Boronophenylalanine; Boron B 10 BPA;
NCIt related terms : BOROFALAN B-10; Borofalan-10B;
NCIt definition : A boronated phenylalanine and boron (boron-10) carrier that may be used in boron neutron
capture therapy (BNCT), with potential antineoplastic activity. Upon administration,
borofalan (10B) is absorbed mostly by tumor cells. When exposed to neutron irradiation,
borofalan (10B) absorbs neutrons and self-destructs releasing short-range alpha radiation
and 'recoil' lithium in tumor cells, resulting in alpha radiation-induced tumor cell
death. This highly selective, localized radiotargeting of tumor cells spares adjacent
normal tissues.;
UNII : 963AI80S1B;
InChIKey : NFIVJOSXJDORSP-ULMHTEDTSA-N;
CAS number : 80994-59-8;
Molecule name : SPM 011; SPM-011;
NCI Metathesaurus CUI : CL1406060;
Codes from synonyms : 119973;
Origin ID : C171879;
UMLS CUI : C5419351;
Semantic type(s)
- concept_is_in_subset
