NCIt definition : An orally bioavailable, peptidomimetic inhibitor of hepatitis C virus (HCV) NS3/4A
protease, with antiviral activity against HCV and potential antiviral activity against
SARS-CoV-2. Upon oral administration, danoprevir binds to and blocks the activity
of HCV NS3/4A protease. This prevents the cleavage and processing of HCV viral proteins
leading to the inhibition of HCV replication. Danoprevir may also bind to and block
of the activity of SARS-CoV-2 protease. This prevents the cleavage and processing
of SARS-CoV-2 viral proteins leading to the inhibition of SARS-CoV-2 replication.
NS3/4A, a chymotrypsin-like serine protease, is responsible for cleavage at four sites
of the HCV polyprotein to form the viral proteins required for HCV replication. It
plays a key role in the HCV viral replication process. HCV infection is associated
with the development of hepatocellular carcinoma (HCC). A chymotrypsin-like protease
is responsible for cleavage of the SARS-CoV-2 viral polyprotein to form the RNA replicase-transcriptase
complex, which plays a key role in the SARS-CoV-2 viral transcription and replication
process.;
UNII : 911Z9PCQ5F;
InChIKey : ZVTDLPBHTSMEJZ-JSZLBQEHSA-N;
CAS number : 850876-88-9;
Molecule name : ITMN 191; RG 7227; ITMN-191; RG-7227;