Preferred Label : Tinurilimab;
NCIt synonyms : Anti-CEACAM6 Antibody BAY1834942;
NCIt definition : A humanized monoclonal antibody directed against the immune checkpoint regulator carcinoembryonic
antigen-related cell adhesion molecule 6 (CEACAM6; CEACAM-6; CD66c), with potential
immune checkpoint inhibitory and antineoplastic activities. Upon administration,tinurilimab
targets, binds to and blocks the activity of CEACAM6 expressed on various tumor and
immune cells, including T-cells. Blocking CEACAM6 signaling abrogates effector T-cell
inhibition, activates antigen-specific T-lymphocytes, increases secretion of T-cell
cytokines and effector molecules, and enhances cytotoxic T-cell-mediated tumor cell
lysis, which results in a reduction in tumor cell proliferation. CEACAM6, an immune
checkpoint receptor, is associated with tumor-mediated immune suppression. Elevated
CEACAM6 expression is associated with advanced tumor stages and poor prognosis.;
UNII : 227KIR246G;
CAS number : 2226224-30-0;
Molecule name : BAY 1834942; BAY-1834942;
NCI Metathesaurus CUI : CL951555;
Origin ID : C171841;
UMLS CUI : C5421344;
CISMeF manual mappings
- Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
