Preferred Label : Astegolimab;
NCIt synonyms : AMG 282;
NCIt definition : A human monoclonal antibody directed against ST2, a receptor for the human inflammatory
cytokine interleukin-33 (IL-33), with potential anti-inflammatory activity. Upon administration,
astegolimab targets and binds to ST2. This prevents the binding of IL-33 to its receptor
complex ST2 (IL1RL1) and IL-1 receptor accessory protein (IL-1RAcP). This inhibits
the activation of IL-33/ST2-mediated signal transduction pathways. This may inhibit
IL-33/ST2-mediated inflammation. IL-33 belongs to the IL-1 cytokine family and plays
a key role in the modulation of inflammatory and neurodegenerative conditions. IL-33
is constitutively expressed at high levels in the nuclei of many cell types including
endothelial, glial and some immune cells. It is involved in innate and adaptive immune
responses via interaction with its receptor ST2, which is expressed on various immune
cells, including macrophages, neutrophils, eosinophils, basophils, mast cells, type
2 helper T cells (Th2), regulatory T cells (Tregs), and group 2 innate lymphoid cells
(ILC2s).;
UNII : 27TW751DTH;
CAS number : 2173054-79-8;
Molecule name : RO-7187807; MSTT-1041A; RG6149;
NCI Metathesaurus CUI : CL1406019;
Origin ID : C171824;
UMLS CUI : C5421343;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
